Amyloid beta 1-40 Recombinant Rabbit mAb (SDT-1548-54)

Amyloid beta 1-40 (Aβ1-40) is a 40-residue peptide derived from the amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. It is one of the major forms of amyloid beta peptides, along with Aβ1-42, and constitutes a significant portion of the amyloid plaques found in the brains of Alzheimer's disease patients. Unlike its more pathogenic counterpart Aβ1-42, Aβ1-40 is considered less prone to aggregation and plaque formation. However, it still plays a role in the disease pathology and has been implicated in neuroinflammation and cerebrovascular dysfunction. Additionally, Aβ1-40 has been found to have non-pathological functions and is more abundant in the brain compared to Aβ1-42.