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Amenian hamster Anti-Mouse CD3 Antibody (S-R488)

Amenian hamster Anti-Mouse CD3 Antibody (S-R488)

Catalog Number: S0B8565 Application: FCM Reactivity: Mouse Conjugation: Unconjugated Brand: Starter
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Product Details

Product Specification


Host Armenian hamster
Antigen CD3ε
Synonyms T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; Cd3e
Location Cell membrane
Accession P22646
Clone Number S-R488
Antibody Type Recombinant mAb
Isotype IgG
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Ms

Background

CD3ε protein, also known as CD3E, is a crucial component of the T-cell receptor (TCR) complex, which is essential for T-cell activation and function. It is a single-pass type I membrane glycoprotein that contains one Ig-like domain and one immunoreceptor tyrosine-based activation motif (ITAM) domain. CD3ε, along with CD3γ, CD3δ, and CD3ζ, forms the TCR-CD3 complex, which plays a vital role in coupling antigen recognition to intracellular signal-transduction pathways. This protein is essential for the proper development of T-cells and is involved in the internalization and downregulation of the TCR-CD3 complex on the cell surface. Defects in the CD3ε gene can lead to severe immunodeficiency and have been linked to a susceptibility to type I diabetes in women.

Picture

FC

Flow cytometric analysis of C57BL/6 mouse splenocytes labeling Mouse CD3 at 1/200 (1 μg) dilution / (Red) compared with a Amenian hamster IgG, Isotype Control / (Black). Goat Anti - Amenian hamster IgG Alexa Fluor® 488 was used as the secondary antibody.