Flow cytometric analysis of CD192 expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow were stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b Antibody and either Alexa Fluor® 700 Mouse IgG2b Isotype Control (left panel) or SDT Alexa Fluor® 700 Rat Anti-Mouse CD192 Antibody (right panel) at 2 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Alexa Fluor® 700 Rat Anti-Mouse CD192 Antibody (S-R731)
Alexa Fluor® 700 Rat Anti-Mouse CD192 Antibody (S-R731)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD192 |
| Synonyms | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; JE/FIC receptor; MCP-1 receptor; Cmkbr2 |
| Location | Cell membrane |
| Accession | P51683 |
| Clone Number | S-R731 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Isotype Control | S0B80413 |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Alexa Fluor® 700 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD192, also known as CCR2, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is primarily expressed on monocytes, macrophages, basophils, dendritic cells, and some T cells. CD192 acts as a receptor for several chemokines, including monocyte chemoattractant protein-1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. This receptor plays a crucial role in mediating monocyte chemotaxis and is involved in various inflammatory responses, such as the recruitment of monocytes into tissues during atherosclerosis, rheumatoid arthritis, and tumor formation. Additionally, CD192 has been implicated in the pathogenesis of certain cancers, where it controls the recruitment of activated macrophages that can either promote tumor cytotoxicity or inhibit tumor growth.
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