Flow cytometric analysis of Human CD46 expression on human peripheral blood cells. Human peripheral blood cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either Alexa Fluor® 700 Mouse IgG2a, κ Isotype Control (left panel) or SDT Alexa Fluor® 700 Mouse Anti-Human CD46 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 700 Mouse Anti-Human CD46 Antibody (S-3061)
Alexa Fluor® 700 Mouse Anti-Human CD46 Antibody (S-3061)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD46 |
| Synonyms | Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; MCP; MIC10 |
| Location | Cell membrane |
| Accession | P15529 |
| Clone Number | S-3061 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood cells |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 700 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD46, also known as membrane cofactor protein (MCP), is a type I transmembrane glycoprotein expressed on almost all human nucleated cells that protects host tissues from complement-mediated injury by acting as a cofactor for factor I–mediated proteolytic inactivation of the complement fragments C3b and C4b, and also modulates adaptive immunity by driving IFN-γ–biased Th1 responses and subsequent IL-10–producing T-regulatory cell differentiation, while serving as a cellular receptor for multiple pathogens including measles virus, adenoviruses, HHV-6, and pathogenic Neisseria.
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