Flow cytometric analysis of Human CD183 expression on Human PBMCs (peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Alexa Fluor® 700 Mouse IgG1, κ Isotype Control (left panel) or Alexa Fluor® 700 Mouse Anti-Human CD183 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Alexa Fluor® 700 Mouse Anti-Human CD183 Antibody (S-R583)
Alexa Fluor® 700 Mouse Anti-Human CD183 Antibody (S-R583)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD183 |
| Location | Cell membrane |
| Accession | P49682 |
| Clone Number | S-R583 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 700 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD183, also known as CXCR3, is a 38–41 kD seven-transmembrane G-protein coupled receptor that belongs to the C-X-C chemokine receptor family. It is highly expressed on T cells (Th1), natural killer cells, dendritic cells, mast cells, alveolar macrophages, and some B cells. CXCR3 binds to three chemokines: CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC), and plays a crucial role in mediating chemotaxis and cell proliferation in immune responses. It is involved in the recruitment of inflammatory cells to sites of inflammation and is associated with various inflammatory and autoimmune diseases. Additionally, CXCR3 has different isoforms, such as CXCR3A, CXCR3B, and CXCR3-alt, each with distinct functions.
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