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Alexa Fluor® 700 Mouse Anti-Human CD180 Antibody (G28-8)

Alexa Fluor® 700 Mouse Anti-Human CD180 Antibody (G28-8)

Catalog Number: S0B80514 Application: FCM Reactivity: Hu Conjugation: Alexa Fluor® 700 Brand: Starter
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Product Details

Product Specification


Host Mouse
Antigen CD180
Synonyms CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; LY64; RP105
Location Cell membrane
Accession Q99467
Clone Number G28-8
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.09% sodium azide
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD180, also known as RP105, is a cell-surface glycoprotein of the Toll-like receptor (TLR) family that consists of extracellular leucine-rich repeats and a short cytoplasmic tail, and, when paired with its accessory molecule MD-1, forms the RP105/MD-1 receptor complex that collaborates with TLR4 to recognize bacterial lipopolysaccharide and regulate innate immune signaling in B cells, leading to NF-κB activation, control of B-cell proliferation, and modulation of life-or-death decisions, while its dysfunction is implicated in diseases such as chronic lymphocytic leukemia and Kawasaki disease.

Picture

FC

Flow cytometric analysis of human CD180 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and SDT Alexa Fluor® 700 Mouse Anti-Human CD180 Antibody at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.