Flow cytometric analysis of Mouse CD198 expression on C57BL/6 mouse thymocytes. C57BL/6 mouse thymocytes were stained with Alexa Fluor® 488 Rat Anti-Mouse CD4 Antibody and either Alexa Fluor® 647 Rat IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD198 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rat Anti-Mouse CD198 Antibody (S-R626)
Alexa Fluor® 647 Rat Anti-Mouse CD198 Antibody (S-R626)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD198 |
| Synonyms | C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8 |
| Location | Cell membrane |
| Accession | P56484 |
| Clone Number | S-R626 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD198, also known as C-C chemokine receptor type 8 (CCR8), is a 41 kD G-protein coupled receptor with seven transmembrane regions. It belongs to the C-C chemokine receptor family and is expressed in various cell types, including a subset of thymocytes, Tregs, NKT cells, Th2-polarized cells, macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 plays a crucial role in mediating chemotaxis and is involved in the apoptosis of thymocytes. It is also associated with allergic inflammation and has potential as a therapeutic target for conditions like HIV-1 infection. The receptor binds to ligands such as CCL1 and CCL16 and has high affinity for viral chemokines like vMIP-I, vMIP-II, and vMCC-I.
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