Alexa Fluor® 647 Rat Anti-Mouse CD144 Antibody (S-R719)

CD144, also known as VE-cadherin or cadherin-5, is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail, expressed almost exclusively at the adherens junctions of endothelial cells in blood and lymphatic vessels, where it mediates homophilic adhesion, controls endothelial permeability, maintains vascular integrity, promotes endothelial quiescence and tubulogenesis, and is indispensable for embryonic vascular development since its genetic deletion or truncation causes mid-gestational lethality due to vessel disassembly and hemorrhage.