Flow cytometric analysis of Human XCR1 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD141 Antibody and either SDT FITC Rat IgG2a, κ Isotype Control (Left panel) or FITC Rat Anti-Human XCR1 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rat Anti-Human XCR1 Antibody (S-3294)
Alexa Fluor® 647 Rat Anti-Human XCR1 Antibody (S-3294)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | XCR1 |
| Synonyms | Chemokine XC receptor 1; G-protein coupled receptor 5; Lymphotactin receptor; XC chemokine receptor 1; CCXCR1; GPR5 |
| Location | Cell membrane |
| Accession | P46094 |
| Clone Number | S-3294 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
XCR1 is a conserved, 7-transmembrane G-protein-coupled receptor selectively expressed on CD8α⁺ and CD103⁺ classical dendritic cells; its exclusive ligand XCL1 is secreted by activated CD8⁺ T and NK cells, forming a chemotactic feedback loop that recruits antigen-loaded DCs into lymphoid tissue and optimizes cross-presentation, Th1 cytotoxicity and antiviral/antitumor immunity, making the XCR1–XCL1 axis an emerging target for cancer immunotherapy and vaccine adjuvant design.
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