Flow cytometric analysis of Mouse NK1.1/CD161 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Rat Anti-Mouse CD49b antibody and either Alexa Fluor® 647 Rabbit IgG Isotype Control (Left panel) or SDT Alexa Fluor® 647 Rabbit Anti-Mouse NK1.1/CD161 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rabbit Anti-Mouse NK1.1/CD161 Antibody (S-428-32)
Alexa Fluor® 647 Rabbit Anti-Mouse NK1.1/CD161 Antibody (S-428-32)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | NK1.1/CD161 |
| Synonyms | Killer cell lectin-like receptor subfamily B member 1C; CD161 antigen-like family member C; Lymphocyte antigen 55c (Ly-55c); NK1.1; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40 (NKR-P1 40); CD161c; Ly55c; Nkrp1c; Klrb1c |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P27814 |
| Clone Number | S-428-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein A |
| Concentration | 0.02mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
NK1.1/CD161, also known as KLRB1, is a receptor protein expressed on the surface of natural killer (NK) cells and certain T cells. In mice, NK1.1 belongs to the NKRP1 receptor family and interacts with C-type lectin-related molecules, playing a role in immune recognition and regulation. In humans, CD161 on NK cells interacts with ligands such as LLT1, and this interaction is inhibitory, helping to regulate NK cell function. Additionally, CD161 is involved in intracellular signaling pathways, such as the AKT pathway, which influences NK cell activity. This protein is also a marker for different subsets of NK cells, with high expression in certain mature and cytotoxic NK cell populations.
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