Alexa Fluor® 647 Rabbit Anti-Human CD35 Antibody (S-1294-26)

CD35, also known as Complement Receptor 1 (CR1), is a large single-chain transmembrane glycoprotein belonging to the regulators of complement activation (RCA) family, primarily expressed on the surface of erythrocytes, leukocytes, glomerular podocytes, and dendritic cells. Structurally characterized by multiple short consensus repeats (SCRs) that bind complement fragments C3b and C4b, CD35 plays a pivotal dual role in the immune system: it acts as a cofactor for Factor I-mediated cleavage of C3b and C4b, thereby inhibiting the formation of C3 convertases and protecting host tissues from excessive complement damage, while simultaneously facilitating the clearance of immune complexes by transporting them via erythrocytes to the liver and spleen for removal by macrophages. Beyond its regulatory function in the complement cascade, CD35 serves as a receptor for various pathogens, including Plasmodium falciparum-infected red blood cells and certain viruses, and has been implicated in the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE) due to its critical involvement in maintaining immune homeostasis and preventing the deposition of immune complexes in tissues.