Flow cytometric analysis of Mouse CD244.2 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Rat Anti-Mouse CD49b Antibody and either Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Mouse CD244.2 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Mouse Anti-Mouse CD244.2 Antibody (S-R736)
Alexa Fluor® 647 Mouse Anti-Mouse CD244.2 Antibody (S-R736)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD244.2 |
| Synonyms | Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4 (NKR2B4); Non-MHC restricted killing associated; SLAM family member 4 (SLAMF4); Signaling lymphocytic activation molecule 4; 2b4; Nmrk; Cd244 |
| Location | Cell membrane |
| Accession | Q07763 |
| Clone Number | S-R736 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD244.2 protein, also known as natural killer cell receptor 2B4 isoform 2 precursor, is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family. It is encoded by the CD244 gene and primarily expressed in various immune cells such as NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. This protein mainly binds to its ligand CD48, another SLAM family member, to transmit stimulatory or inhibitory signals and regulate immune responses, including NK cell-mediated cytotoxicity, leukocyte activation, and cytokine production. CD244.2 plays a crucial role in the immune system and has potential as a therapeutic target in cancer and other immune-related diseases.
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