Flow cytometric analysis of Human CD193 expression on Human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with FITC Mouse Anti-Human CD16 Antibody and either Alexa Fluor® 647 Mouse IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD193 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Mouse Anti-Human CD193 Antibody (S-3013)
Alexa Fluor® 647 Mouse Anti-Human CD193 Antibody (S-3013)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD193 |
| Synonyms | C-C chemokine receptor type 3; C C CKR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR 3; CKR3; Eosinophil eotaxin receptor; CMKBR3 |
| Location | Cell membrane |
| Accession | P51677 |
| Clone Number | S-3013 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD193, also designated CCR3, is a seven-transmembrane G protein-coupled receptor that serves as the high-affinity receptor for the CC chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13) and binds RANTES, MCP-3 and MCP-4 with lower affinity; it is prominently expressed on eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34⁺ hematopoietic progenitors, Th2 lymphocytes and keratinocytes, mediating eosinophil chemotaxis and effector functions in allergic inflammation such as asthma and rhinitis, and also functions as a co-receptor for HIV-1 and HIV-2 entry .
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