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Alexa Fluor® 647 Mouse Anti-Human CD192 Antibody (S-2971)

Alexa Fluor® 647 Mouse Anti-Human CD192 Antibody (S-2971)

Catalog Number: S0B80291 Application: FCM Reactivity: Hu Conjugation: Alexa Fluor® 647 Brand: Starter
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$85 USD
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Product Details

Product Specification


Host Mouse
Antigen CD192
Synonyms C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor (MCP-1-R); CMKBR2
Location Cell membrane
Accession P41597
Clone Number S-2971
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 647
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.09% sodium azide
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD192, also called CCR2, is a 42 kDa seven-transmembrane G-protein-coupled receptor expressed mainly on monocytes, macrophages and basophils that binds the chemokines MCP-1 (CCL2), MCP-3 (CCL7) and MCP-4 (CCL13), triggers intracellular calcium flux and inhibition of adenylyl cyclase, thereby directing chemotaxis and bone marrow homeostasis, and has been implicated in inflammatory diseases such as rheumatoid arthritis, atherosclerosis and cancer as well as serving as an alternative HIV-1 coreceptor with CD4.

Picture

FC

Flow cytometric analysis of CD192 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD14 Antibody and either Alexa Fluor® 647 Mouse IgG2a, k Isotype Control (left panel) or Alexa Fluor® 647 Mouse Anti-Human CD192 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.