2e5 of transient transfected anti- BCMA/TNFRSF17 ScFv CAR-293 cells were stained with 0.1ug Alexa Fluor 647-Labeled BCMA/TNFRSF17 His Tag Protein, Human, (Cat. No. UA011246) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). Alexa Fluor 647 signal was used to evaluate the binding activity.
2e5 of transient transfected anti- BCMA/TNFRSF17 ScFv CAR-293 cells were stained with 0.01ug BCMA/TNFRSF17 His Tag Protein, Human (Cat. No. UA010083) (Fig. D). Alexa Fluor 647 signal was used to evaluate the binding activity.
2e5 of transient transfected anti- BCMA/TNFRSF17 ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.
Alexa Fluor 647-Labeled BCMA/TNFRSF17 His Tag Protein, Human
Alexa Fluor 647-Labeled BCMA/TNFRSF17 His Tag Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD269,TNFRSF17,BCM,BCMA,TNFRSF13A,Herpes virus entry mediator A,Herpesvirus entry mediator A,HveA,Tumor necrosis factor receptor-like 2,TR2 |
| Accession | Q02223-1 |
| Amino Acid Sequence | Met1-Ala54 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 15-19kDa |
| Conjugation | Alexa Fluor® 647 |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage |
· 12 months from date of receipt stored at --20 to -80℃. · 1 week, 2 to 8℃ under sterile conditions · Recommend to aliquot the protein into smaller quantities for optimal storage. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Gene ID: 608, updated on 18-Aug-2023. |
Background
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Guidelines
Please conduct the experiments strictly according to the recommended dosage. If the grouping is not clear, the recommended dosage can be increased by 2 to 5 times.
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