Flow cytometric analysis of mouse CD194 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD4 Antibody and either Alexa Fluor® 647 Armenian hamster IgG Isotype Control (left panel) or SDT Alexa Fluor® 647 Armenian hamster Anti-Mouse CD194 Antibody (right panel) at 0.5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™software.
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD194 Antibody (S-R694)
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD194 Antibody (S-R694)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | CD194 |
| Synonyms | C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; CD194; Cmkbr4 |
| Location | Cell membrane |
| Accession | P51680 |
| Clone Number | S-R694 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse thymocytes |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 0.25μg per million cells in 100μl volume | Ms |
Background
CD194, also known as CCR4 (C-C chemokine receptor type 4), is a G protein-coupled receptor with seven transmembrane domains. It is expressed on various immune cells, including CD4+ T cells (especially Th2 cells), regulatory T cells (Tregs), basophils, monocytes, and natural killer (NK) cells. CCR4 binds to chemokines such as CCL17 (TARC) and CCL22 (MDC), playing a crucial role in the recruitment of memory T cells and immune responses in conditions like atopic dermatitis and asthma. Additionally, CCR4 is involved in tumor biology, with high expression levels associated with tumor infiltration and prognosis in both hematological malignancies and solid tumors, making it a potential target for cancer immunotherapy.
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