Flow cytometric analysis of mouse CD31 expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with APC Rat Anti-Mouse CD45R/B220 antibody and either Alexa Fluor® 488 Rat IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Rat Anti- Mouse CD31 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Rat Anti-Mouse CD31 Antibody (S-2908)
Alexa Fluor® 488 Rat Anti-Mouse CD31 Antibody (S-2908)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD31 |
| Synonyms | Platelet endothelial cell adhesion molecule; PECAM-1; Pecam; Pecam1 |
| Location | Cell membrane |
| Accession | Q08481 |
| Clone Number | S-2908 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD31, also known as platelet endothelial cell adhesion molecule (PECAM-1), is a glycoprotein encoded by the PECAM1 gene and expressed on endothelial cells, platelets, and various types of leukocytes. It is a type I transmembrane protein with six extracellular immunoglobulin-like domains, a transmembrane segment, and a short cytoplasmic tail. CD31 plays crucial roles in cell-cell adhesion, immune response, and vascular integrity. It facilitates leukocyte transmigration during inflammation, maintains endothelial cell junctions, and regulates vascular permeability. Additionally, CD31 is involved in angiogenesis and has potential implications in cancer metastasis and thrombus formation. Its expression and function are also implicated in various diseases, including atherosclerosis and Alzheimer's disease.
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