Flow cytometric analysis of CD360 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either Alexa Fluor® 488 Mouse IgG1, k Isotype Control (left panel) or Alexa Fluor® 488 Mouse Anti-Human CD360 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD360 Antibody (S-3285)
Alexa Fluor® 488 Mouse Anti-Human CD360 Antibody (S-3285)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD360 |
| Synonyms | Interleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; NILR; IL21R |
| Location | Membrane |
| Accession | Q9HBE5 |
| Clone Number | S-3285 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B1519 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
The CD360 protein, also known as the B-cell receptor CD360 or Leukocyte Immunoglobulin-Like Receptor B1 (LILRB1), is an inhibitory receptor primarily expressed on the surface of immune cells such as B cells, monocytes, dendritic cells, and NK cells. Belonging to the Leukocyte Immunoglobulin-Like Receptor (LILR) family, it recognizes ligands like MHC class I molecules (e.g., HLA-G) and transmits inhibitory signals, thereby negatively regulating immune responses. It plays a critical role in maintaining immune homeostasis, preventing excessive activation, and mediating immune escape. Dysregulation of its function is closely associated with autoimmune diseases, infections, and tumor immune evasion, making it a potential target for immunotherapy research.
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