SH-SY5Y (human neuroblastoma epithelial cell) were stained with either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (black line histogram) or Alexa Fluor® 488 Mouse anti-Human CD271 Antibody (red line histogram) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD271 Antibody (S-2902)
Alexa Fluor® 488 Mouse Anti-Human CD271 Antibody (S-2902)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD271 |
| Synonyms | Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor); Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; p75 ICD; TNFRSF16; NGFR |
| Location | Cytoplasm, Cell membrane |
| Accession | P08138 |
| Clone Number | S-2902 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B1519 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | SH-SY5Y |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD271 (also termed p75NTR or NGFR) is a low-affinity neurotrophin receptor that functions as a context-dependent molecular switch, promoting either differentiation and apoptosis in normal tissues or survival, stemness and metastasis in cancers by activating MEK/ERK, RhoA/ROCK and other downstream cascades, and its expression marks therapy-resistant melanoma-initiating cells, drives phenotype switching in cutaneous squamous cell carcinoma, correlates with aggressive disease in medulloblastoma and neurofibromatosis tumors, and orchestrates osteogenic commitment of ectomesenchymal stem cells during craniofacial bone development.
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