Alexa Fluor® 488 Mouse Anti-Human CD107a Antibody (S-3027)

CD107a, also termed lysosome-associated membrane protein-1 (LAMP-1), is a heavily glycosylated type-I transmembrane glycoprotein encoded by the LAMP1 gene, constituting ~50 % of all proteins in the lysosomal membrane where its dense carbohydrate coat protects against self-digestion, while in immune cells it functions as a universally accepted surrogate marker of cytotoxic degranulation because, upon NK- or CD8⁺ T-cell activation, the lytic granules fuse with the plasma membrane and transiently expose CD107a on the cell surface, enabling flow-cytometric quantification of perforin/granzyme release; beyond immunology, CD107a shuttles between lysosomes, endosomes and the plasma membrane, provides carbohydrate ligands for selectins to facilitate leukocyte adhesion, and its overexpression on tumor cells correlates with enhanced metastatic potential .