Alexa Fluor® 488 Armenian hamster Anti-Mouse CD183 Antibody (CXCR3-173)

CD183, also known as CXCR3, is a 40-kDa, seven-transmembrane G-protein-coupled receptor encoded on chromosome Xq13 that selectively binds the IFN-γ-inducible chemokines CXCL9, CXCL10 and CXCL11; upon ligation it triggers Gi-mediated signaling cascades (MAPK, PI3K/AKT, PLCβ3/μ-calpain, cAMP/PKA and p38MAPK) that induce rapid integrin activation, cytoskeletal rearrangement and chemotactic migration of activated/memory CD4⁺ and CD8⁺ T cells, NK cells and endothelial cells, thereby orchestrating Th1-oriented inflammatory responses, anti-viral immunity and angiostasis; the receptor exists in three alternatively spliced isoforms (CXCR3-A, -B and -alt) that differ in their C-termini and third intracellular loop, enabling ligand-specific functional bias—CXCR3-A promotes proliferation, survival and invasion, whereas CXCR3-B mediates growth inhibition, apoptosis and vascular suppression—and is prominently expressed in inflamed tissues and various cancers, making it a key therapeutic target for autoimmune, neoplastic and infectious diseases.