Flow cytometric analysis of Mouse CD103 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with PE Rat Anti-Mouse CD3e Antibody and either Alexa Fluor® 488 Armenian hamster IgG Isotype Control (Left panel) or SDT Alexa Fluor® 488 Armenian hamster Anti-Mouse CD103 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Armenian hamster Anti-Mouse CD103 Antibody (S-R692)
Alexa Fluor® 488 Armenian hamster Anti-Mouse CD103 Antibody (S-R692)
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Product Details
Product Details
Product Specification
| Synonyms | Integrin alpha-E; Integrin alpha M290; Itgae |
| Location | Membrane |
| Accession | Q60677 |
| Clone Number | S-R692 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on the surface of various immune cells, including intraepithelial lymphocytes (IELs), tissue-resident memory T cells, and dendritic cells. It plays a crucial role in cell adhesion and migration through its interaction with E-cadherin, a cellular adhesion molecule found on epithelial cells. CD103 is a hallmark of immune cells residing in mucosal tissues such as the gut, lung, and skin, and is involved in immune surveillance and regulation. In cancer, CD103+ immune cells are associated with immune checkpoint pathways and can serve as predictive markers for immunotherapy response in various malignancies.
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