ADAMTS1 Recombinant Rabbit mAb (S-5953)

ADAMTS1 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 1) is a secreted multi-domain zinc-dependent metalloproteinase belonging to the ADAMTS family, which plays important roles in various physiological and pathological processes including angiogenesis, organ development, inflammation, and tumor progression. Its structural features include a signal peptide, propeptide domain, catalytic domain, disintegrin-like domain, thrombospondin type 1 motifs, and a cysteine-rich domain, among which the catalytic domain is responsible for cleaving extracellular matrix components such as proteoglycans (e.g., versican), while the thrombospondin type 1 motifs mediate its binding to glycosaminoglycans like heparan sulfate, regulating protein localization and activity. The expression of ADAMTS1 is regulated by various cytokines and growth factors, including epidermal growth factor, transforming growth factor-β, and tumor necrosis factor-α. It exerts anti-angiogenic effects by modulating vascular endothelial growth factor signaling pathways and inhibiting endothelial cell proliferation, thereby suppressing tumor angiogenesis. Furthermore, ADAMTS1 participates in inflammatory responses and tissue remodeling through the cleavage of substrates such as versican, and its aberrant expression is closely associated with atherosclerosis, arthritis, and the metastasis of various malignancies, rendering it a promising diagnostic biomarker and therapeutic target.