WB result of Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb
Primary antibody: Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: Raji whole cell lysate 20 µg
Lane 2: PC-3 whole cell lysate 20 µg
Lane 3: JAR whole cell lysate 20 µg
Lane 4: U-87 MG whole cell lysate 20 µg
Lane 5: A549 whole cell lysate 20 µg
Lane 6: HeLa whole cell lysate 20 µg
Negative control: Raji whole cell lysate
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 57 kDa
Observed MW: 54 kDa
Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb (S-2058-256)
Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb (S-2058-256)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Activin receptor type 1 (ACVR1) |
| Synonyms | Activin receptor type-1; Activin receptor type I (ACTR-I); Activin receptor-like kinase 2 (ALK-2); Serine/threonine-protein kinase receptor R1 (SKR1); TGF-B superfamily receptor type I (TSR-I); ACVRLK2 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q04771 |
| Clone Number | S-2058-256 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Predicted Reactivity | Bv, Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt, Mk |
Background
Activin receptor type 1 (ACVR1, also known as ALK-2) is a bone morphogenetic protein (BMP) type I serine/threonine kinase receptor of the TGF-β superfamily that, upon ligand binding and phosphorylation by cognate type II receptors, propagates signals by phosphorylating SMAD1/5/8 transcription factors to orchestrate embryonic patterning, skeletal development, and postnatal tissue repair, while pathogenic gain-of-function mutations (e.g., R206H) drive the rare congenital disorder fibrodysplasia ossificans progressiva through aberrant chondro-osseous differentiation and also contribute to the oncogenesis of diffuse intrinsic pontine glioma by hyperactivating the BMP–SMAD axis .
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Picture
Western Blot
WB result of Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb
Primary antibody: Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: mouse brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 57 kDa
Observed MW: 54 kDa
WB result of Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb
Primary antibody: Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: rat brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 57 kDa
Observed MW: 54 kDa
WB result of Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb
Primary antibody: Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: COS-7 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 57 kDa
Observed MW: 54 kDa
