AACT Recombinant Rabbit mAb (SDT-897-21)
AACT Recombinant Rabbit mAb (SDT-897-21)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | AACT |
| Synonyms | Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; AACT; SERPINA3 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P01011 |
| Clone Number | SDT-897-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Alpha-1-antichymotrypsin (AACT), also known as SERPINA3, is a serine protease inhibitor primarily synthesized in the liver and secreted into the blood. It is an acute-phase protein involved in the inflammatory response and has a molecular weight of approximately 47.651 kDa. AACT plays a crucial role in inhibiting proteases such as cathepsin G and chymase, thereby protecting cells and tissues from proteolytic damage. Elevated levels of AACT have been observed in various diseases, including Alzheimer's disease, heart failure, and multiple cancers. Its expression and glycosylation patterns can serve as potential biomarkers for disease diagnosis and prognosis.
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