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FGF-8e Protein, Human

FGF-8e Protein, Human

Catalog Number: UA040049 Brand: UA BIOSCIENCE
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$120 USD
$120 USD
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Product Details

Product Specification


Species Human
Synonyms FGF-8e,AIGF,HBGF 8e,KAL6
Accession P55075-1
Amino Acid Sequence

Gln23-Arg233
Expression System E.coli
Molecular Weight

26kDa
Purity ＞95% by SDS-PAGE and HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized powder
Storage Buffer

20mM PB, 150mM NaCl, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1、Valve E M. et al. (2001) Increased expression of FGF-8 isoforms and FGF receptors in human premalignant prostatic intraepithelial neoplasia lesions and prostate cancer. Lab Invest. 81(6): 815-826.

Background

Fibroblast growth factor 8e (FGF-8e), a secreted heparin-binding protein, is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Alternative splicing of fgf-8 gene gives rise to potentially four (a, b, e, f) different protein isoforms in human. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an organizing and inducing role during gastrulation, and regulates patterning of the midbrain/hindbrain, eye, ear, limb and heart in the embryo.

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Bioactivity

Measured in a cell proliferation assay using Balb/3T3 mouse fibroblast cells, the EC50 for this effect is 120-177 ng/ml.

SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).

RP-HPLC