Fc γ RIIB/CD32b His Tag Protein, Mouse
Fc γ RIIB/CD32b His Tag Protein, Mouse
Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Fc gamma RIIB , CD32b;;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32 |
| Accession | P08101-1 |
| Amino Acid Sequence | Thr30-Arg208, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 33-43kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Fc γ RIIB, also known as CD32b, is a low affinity inhibitory receptor for the Fc part of the IgG molecule. It is a single-channel type I membrane protein with two IgG-like C2 (immunoglobulin-like) domains. Fc γ RIIB is expressed on B cells, macrophages, neutrophils, mast cells and bone marrow dendritic cells, and participates in B cell phagocytosis of immune complexes and regulation of antibody production. In some cases, it can promote cell apoptosis. CD32b may also be a target for monoclonal antibodies in the treatment of malignant tumors.
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SDS-PAGE
RP-HPLC
SPR
NA/LE Mouse anti-human CD3 mAb (Cat. No. S0B0009) immobilized on CM5 Chip can bind Fc γ RIIB/CD32b His Tag Protein, Mouse (Cat. No. UA020015) with an affinity constant of 375 nM as determined in a SPR assay.
