Human PVRIG Protein, hFc Tag

Catalog Number: S0A0182 Brand: Starter

Price:

$95 USD

Size: 10μg 25μg 50μg

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Product Details

Product Specification

Species	Human
Synonyms	Transmembrane protein PVRIG, CD112 receptor (CD112R), Poliovirus receptor-related immunoglobulin domain-containing protein, PVRIG, C7orf15
Accession	Q6DKI7
Amino Acid Sequence	Protein sequence (Q6DKI7, Thr41-Asp171, with C-hFc tag) TPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRAD
Expression System	HEK293
Molecular Weight	Predicted MW: 39.7 kDaObserved MW: 54 kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	with C-hFc Tag
Physical Appearance	Lyophilized powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

PVRIG (also known as CD112R) is an immune checkpoint protein belonging to the DNAM-1/TIGIT/CD96 family. It interacts with its ligand, PVRL2 (CD112), which is expressed on antigen-presenting cells and tumor cells. PVRIG functions as a co-inhibitory receptor, primarily expressed on T cells and NK cells, and plays a critical role in modulating immune responses. By binding to PVRL2, PVRIG suppresses T-cell and NK-cell activation, contributing to immune evasion in cancers.