2μg (R: reducing condition, N: non-reducing condition).
Biotinylated VEGF-R1/Flt-1 His&Avi Tag Protein, Human
Biotinylated VEGF-R1/Flt-1 His&Avi Tag Protein, Human
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$430 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | FLT, VEGFR1 |
| Accession | P17948 |
| Amino Acid Sequence | Ser27-Asn756with His&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 130-180kDa (Reducing) |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation |
| Stability & Storage |
· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃under sterile conditions after reconstitution. · 1 week, 2 to 8℃under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Lam F, Warwick T, Oo J A, et al. LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing[J]. Molecular Therapy, 2026, 34(7): 4323-4338. 2.Angom R S, Li Z, Rachamala H K, et al. VEGFR1-mediated neuronal cell death following Aß1-42 oligomers treatment: implications in AD pathogenesis[J]. Alzheimer's & Dementia, 2024. 3.Kang M J, Roh K H, Lee J S, et al. Vascular endothelial growth factor receptor 1 targeting fusion polypeptides with stimuli-responsiveness for anti-angiogenesis[J]. ACS Applied Materials & Interfaces, 2023, 15(27): 32201-32214. |
Background
Vascular endothelial growth factor receptor 1 (VEGFR-1), also known as Fms-like tyrosine kinase-1 (FLT1), is a key member of the VEGF receptor family. Structurally, it comprises seven extracellular immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain, and exists in two isoforms: membrane-bound VEGFR-1 and a soluble splice variant (sFLT1). VEGFR-1 binds VEGF-A, VEGF-B, and PlGF, and regulates not only angiogenesis and endothelial function but also inflammation, macrophage activation, and neuronal survival. sFLT1 acts as a decoy receptor that negatively modulates VEGF signaling, and its dysregulation is closely associated with preeclampsia and diabetic nephropathy. Membrane-bound VEGFR-1 plays complex roles in tumor angiogenesis, neuronal injury in Alzheimer's disease, and cardiovascular disorders, making it an important target for gene therapy and anti-angiogenic therapeutics.
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SDS-PAGE
SEC-HPLC
The purity of Biotinylated VEGF-R1/Flt-1 His&Avi Tag Protein, Human is more than 95% determined by SEC-HPLC.
ELISA
Immobilized Human PlGF Protein, His Tag (Cat. No. S0A0018) at 2 μg/mL (100 μL/well) can bind Biotinylated VEGF-R1/Flt-1 His&Avi Tag Protein, Human (Cat. No. UA016237) with a linear range of 4.9-22 ng/mL
Immobilized Human VEGF 165, His tag (Cat. No. S0A4034) at 2 μg/mL (100 μL/well) can bind Biotinylated VEGF-R1/Flt-1 His&Avi Tag Protein, Human (Cat. No. UA016237) with a linear range of 8.5-14 ng/mL
