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C4d Recombinant Rabbit mAb (SDT-R021)

C4d Recombinant Rabbit mAb (SDT-R021)

Catalog Number: S0B2061 Application: IHC-P Reactivity: Human Conjugation: Unconjugated Brand: Starter
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Product Details

Product Specification


Host Rabbit
Antigen C4d
Synonyms n/a
Immunogen N/A
Location Secreted
Accession P0C0L5
Clone Number SDT-R021
Antibody Type Rabbit mAb
Application IHC-P
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:500 null

Background

Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response.C4d is a degradation product of complement activator. If C4d is high in the tumor of patients, its survival period will be reduced; Complement fragment C4d can be used as a biomarker for early diagnosis and prognosis prediction of lung cancer patients.

Picture

Immunohistochemistry

IHC shows positive staining in paraffin-embedded human tonsil.

Anti-C4d antibody was used at 1/500 dilution, followed by a Goat Anti-Rabbit IgG H&L (HRP) ready to use.

Counterstained with hematoxylin.

Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

IHC shows positive staining in paraffin-embedded human liver.

Anti-C4d antibody was used at 1/500 dilution, followed by a Goat Anti-Rabbit IgG H&L (HRP) ready to use.

Counterstained with hematoxylin.

Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

IHC shows positive staining in paraffin-embedded human lung cancer. Anti-C4d antibody was used at 1/500 dilution, followed by a Goat Anti-Rabbit IgG H&L (HRP) ready to use.

Counterstained with hematoxylin.

Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

IHC shows positive staining in paraffin-embedded human breast cancer. Anti-C4d antibody was used at 1/500 dilution, followed by a Goat Anti-Rabbit IgG H&L (HRP) ready to use.

Counterstained with hematoxylin.

Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.