New Products

1. Claudin-4 protein his tag (detergent, full length), Human

Catalog Number： UA060001

Background:

Claudin 4/CLDN4 is a member of the Claudins family and is one membrane protein of the key Junctions for Tight Junctions. Claudins membrane proteins are composed of four transmembrane domains, and there is a binding domain at the C-terminal, which can bind to proteins in the inner cytoplasm (such as ZO-1), and play an important role in signal transduction. Outside the cell membrane, there are two rings of different lengths (ECL1 and ECL2), which can be in contact with other nearby rings of the same type, forming a tight connection between cells. The extracellular ring is necessary to maintain tight junction function and the integrity of the epithelial barrier. Tight junctions are intercellular adhesion structures located at the tips of epithelial and endothelial cells. Claudins, as an important component of tight junctions, play a role in regulating epithelial cell permeability and maintaining cell polarity. When Claudins protein mutated, the permeability between cells will be affected, which may lead to the occurrence of diseases. More and more studies have revealed that CLDN4 plays a regulatory role in cancer and may be a potential tumor therapeutic target. In fact, a large amount of evidence has shown that Claudins members play an important role in tumor immunotherapy and have great clinical druggability.

Product Data

SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of Claudin4 Protein his tag thrombin site in detergent is greater than 95% as determined by SEC-HPLC.

ELISA

Immobilized Human Claudin-4 Antibody at 2.0μg/mL (100μL/well) can bind Claudin4 membrane Protein with his tag and thrombin site in detergent, Human (Cat. No. UA060001) with EC50 of 2.33-3.61ng/mL.

2. EDNRB protein Flag-His tag (detergent, full length), Human

Catalog Number： UA060002

Background:

Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor, which the activity and function was regulated by G proteins that activate a phosphatidylinositol-calcium second messenger system. The EDNRB membrane protein is widely located in the human body, which involved in the regulation of many physiological activities, such as binding to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum. Endothelin performs its biological function by its receptor (ETR), such as EDNRB. Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors, which can promote tumor growth and metastasis, and can promote anti-apoptosis and angiogenesis.

Product Data

SDS-PAGE

2 μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of EDNRB protein Flag-His tag (detergent, full length), Human is greater than 90% as determined by SEC-HPLC.

ELISA

Immobilized EDNRB Rabbit pAb (A2908) at 0.5μg/mL (100μL/well) can bind EDNRB protein Flag-His tag (detergent, full length), Human (Cat. No. UA060002) with EC50 of 35.50-76.59ng/mL.

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