Nectin-4 Companion Diagnostic Antibodies Guide Precision Therapy for Solid Tumors

1. Literature Information

This work defines Nectin4 (PVRL4) as a validated target for ADC therapy and establishes Nectin4 IHC as a standard companion diagnostic to select patients with urothelial, breast, lung, and digestive cancers.

2. Research Background

Nectin4 is a cell adhesion molecule overexpressed in multiple solid tumors but limited in normal tissues. It promotes proliferation, metastasis, and angiogenesis via PI3K/AKT and JAK/STAT pathways, making it an ideal ADC target.

3. Research Approach

Nectin4 recombinant antibodies enable sensitive and specific IHC detection of membrane expression. Scoring systems quantify staining to determine eligibility for ADC treatment.

4. Research Outcomes

· Nectin4 is expressed in ~90% of metastatic urothelial carcinomas.

· ADCs such as Enfortumab Vedotin deliver potent antitumor efficacy in Nectin4positive cases.

· IHC evaluation focuses on membrane staining intensity and positive ratio.

· Nectin4 status predicts treatment response and prognosis.

5. Product Empowerment

ANT BIO PTE. LTD. offers Nectin4 Recombinant Rabbit mAb (S0B2312).

· High specificity for human Nectin4 with no crossreactivity to other Nectins.

· Validated for IHC (FFPE), WB, flow cytometry, and IF.

· Recombinant design ensures stable and reproducible performance.

· Core tool for ADC companion diagnostics.

6. Brand Mission

ANT BIO PTE. LTD. delivers innovative life science reagents to support precision oncology. Our Starter brand focuses on highquality recombinant antibodies, while Absin and UA complete the solution portfolio.

7. Related Product List

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