Nectin-4 Antibody: A Rising Star in Solid Tumor Targeted Therapy

1. Literature Information

This review summarizes Nectin4 as a leading target for ADCs and emphasizes the essential role of Nectin4 antibodies in patient selection across bladder, breast, ovarian, lung, and other solid tumors.

2. Research Background

Nectin4 is a type I transmembrane protein highly expressed in numerous cancers but minimally present in normal adult tissues. Its restricted expression makes it exceptionally suitable for targeted therapy.

3. Research Approach

IHC using Nectin4specific antibodies detects membrane expression in tumor samples. Standardized scoring supports accurate patient stratification for ADC therapy.

4. Research Outcomes

· Nectin4 drives tumor progression via PI3K/AKT activation.

· High expression in urothelial carcinoma (~80–90%) and TNBC (35–68%).

· Nectin4 ADCs improve survival in platinumresistant and immunotherapyrefractory patients.

· IHC scoring focuses on membrane completeness and intensity.

5. Product Empowerment

ANT BIO PTE. LTD. provides Nectin4 Recombinant Rabbit mAb (S0B2277).

· Exceptional specificity and sensitivity for IHC and pathological diagnosis.

· SRMab® recombinant platform ensures infinite reproducibility.

· Validated for FFPE tissues, flow cytometry, and drug screening.

· Supports global ADC development and precision therapy.

6. Brand Mission

ANT BIO PTE. LTD. provides innovative, reliable life science reagents to accelerate cancer therapy. Our three subbrands cover antibodies, recombinant proteins, and diagnostic kits for global researchers and clinicians.

7. Related Product List

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