InVivoMAb anti-mouse IL-6
14 May 2025
I. Product Introduction
Therapeutic targeting of IL-6 and its receptor.
IL-6 is a 21-28 kDa cytokine expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. It signals through a type I cytokine receptor complex composed of the ligand-binding IL-6Rα chain (CD126) and the signaling component gp130 (also known as CD130). By binding to its receptor, IL-6 influences antigen-specific immune responses, inflammatory reactions, and neuronal development, and it is a major mediator of the acute-phase reaction. The MP5-20F3 monoclonal antibody has been shown to neutralize the biological activity of native or recombinant IL-6.
II. Product Details
| Product No. | S0B1070 |
|---|---|
| Product Name | In vivo anti-Mouse IL-6 Recombinant mAb |
| Host | Rat |
| Antigen Name | IL-6 |
| Synonyms | Interleukin-6, B-cell hybridoma growth factor, Interleukin HP-1 |
| Cellular Location | Secreted |
| Clone No. | S-R550 |
| Antibody Type | Rat mAb |
| Antibody Isotype | IgG1, k |
| Applications | In vivo IL-6 neutralization, in vitro IL-6 neutralization |
| Purification | Protein G |
| Concentration | Lot specific* (generally 2 to 10 mg/ml) |
