2μg (R: reducing condition, N: non-reducing condition).
TPBG/5T4 His Tag Protein, Cynomolgus/Rhesus macaque
TPBG/5T4 His Tag Protein, Cynomolgus/Rhesus macaque
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$215 USD
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Product Details
Product Details
Product Specification
| Amino Acid Sequence | Thr35-Ser355 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, Bridgeman H, Adams R, Brewster A, Jones R, Gwynne S, Blount D, Harrop R, Wright M, Hills R, Gallimore A, Godkin A. Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA Oncol. 2017 Oct 12;3(10):e172579. |
Background
Trophoblast glycoprotein (TPBG), also known as 5T4, is a therapeutic target for several anticancer agents in clinical development. This is primarily due to its high expression in tumors and low expression in normal adult tissues. The TPBG gene encodes a leucine-rich transmembrane glycoprotein that may play a role in cell adhesion. TPBG is expressed by all types of trophoblasts as early as the ninth week of development.
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SDS-PAGE
SEC-HPLC
The purity of TPBG/5T4 His Tag Protein, Cynomolgus/Rhesus macaque is more than 95% determined by SEC-HPLC.
ELISA
Immobilized TPBG/5T4 His Tag Protein, Cynomolgus/Rhesus macaque (Cat. No. UA016152) at 1 μg/mL (100 μL/well) can bind Anti-TPBG Antibody, Human IgG1 with a linear range of 0.65-0.96 ng/mL.
