Immobilized Recombinant Mouse TL1A (N-8His-Flag)at 1μg/ml (100 μl/well) can bind Human TL1A Antibody (9H5)( NC092). The ED50 of Human TL1A Antibody (9H5)is 2.94 ng/ml.
TL1A His&Flag Tag Protein, Mouse
TL1A His&Flag Tag Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI |
| Accession | Q5UBV8 |
| Amino Acid Sequence | Ile76-Leu252,with a 8His, Flag tag at N-terminus |
| Expression System | HEK293 |
| Molecular Weight | 22-30 KDa, reducing conditions |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4. |
| Stability & Storage | Store at ≤-70°C, stable for 6 months after receipt. |
Background
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
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