Flow cytometric analysis of C57BL/6 mouse splenocytes labelling mouse CD335 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with NK1.1 - Alexa Fluor® 647 antibody separately.
Rat Anti-Mouse CD335 Antibody (S-R613)
Rat Anti-Mouse CD335 Antibody (S-R613)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | Mouse CD335 |
| Synonyms | Natural cytotoxicity triggering receptor 1; Activating receptor 1 (mAR-1); Lymphocyte antigen 94; Natural killer cell p46-related protein (NK-p46; NKp46; mNKp46); Ncr1; Ly94 |
| Location | Cell membrane |
| Accession | Q8C567 |
| Clone Number | S-R613 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD335, also known as NKp46, is a 46kDa natural cytotoxicity receptor that belongs to the immunoglobulin superfamily, with two extracellular Ig-like domains. It is selectively expressed on resting and activated natural killer (NK) cells, a subset of T lymphocytes, and certain innate lymphoid cells (ILCs), including ILC1 and a subset of NCR+ ILC3 in the mucosa. CD335 plays a crucial role in the lysis of autologous, allogeneic, or xenogeneic cells by NK cells and is highly conserved in mammals. The receptor's expression and function are vital for maintaining immune balance and defense capabilities, and it may also be involved in other immune cell subsets, suggesting its potential as a target for new immunotherapy strategies.
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