Phospho-c-Myc (Ser62) Recombinant Rabbit mAb (S-3428)

Phospho-c-Myc (Ser62) is the c-Myc transcription factor phosphorylated at serine-62, an essential post-translational modification that stabilizes the protein by preventing ubiquitin-mediated degradation, thereby sustaining c-Myc’s ability to drive expression of genes governing cell-cycle progression, metabolism and apoptosis; this phosphorylation, primarily catalyzed by ERK or CDK kinases in response to mitogenic signals, is tightly balanced by de-phosphorylation at Thr58 to trigger subsequent degradation, and its dysregulation is frequently observed in cancers where elevated phospho-Ser62-c-Myc levels correlate with hyper-proliferation and poor prognosis, making it both a biomarker and a potential therapeutic target.