Flow cytometric analysis of CD102 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD3 Antibody and either PE Rat IgG2a, κ Isotype Control (left panel) or SDT PE Rat Anti-Mouse CD102 Antibody (right panel) at 5 μl/test. Total viable cells, as determined by Fixable Viability Dye 515 (S0D0013), were used for analysis. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
PE Rat Anti-Mouse CD102 Antibody (3C4)
PE Rat Anti-Mouse CD102 Antibody (3C4)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD102 |
| Synonyms | Intercellular adhesion molecule 2; Lymphocyte function-associated AG-1 counter-receptor; Icam-2; Icam2 |
| Location | Membrane, Cell projection |
| Accession | P35330 |
| Clone Number | 3C4 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Isotype Control | Pacific Blue Rat IgG2a Isotype Control (S-R483) |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
CD102, also known as intercellular adhesion molecule 2 (ICAM-2), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is widely expressed on resting lymphocytes, monocytes, platelets, and vascular endothelial cells. CD102 plays a crucial role in immune response by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and mediating adhesive interactions important for lymphocyte recirculation, antigen-specific immune responses, and natural killer cell-mediated clearance. Additionally, it has been identified as a biomarker for long-lived plasma cells in non-human primates and is involved in maintaining the longevity of these cells in the bone marrow. Elevated levels of CD102 have also been associated with conditions like hemorrhagic fever with renal syndrome and idiopathic pulmonary fibrosis.
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