Pacific Blue Mouse Anti-Human CD50 Antibody (S-4993)

CD50, also known as intercellular adhesion molecule-3 (ICAM-3), is a member of the immunoglobulin superfamily and the ICAM family, serving as an important ligand for the integrin LFA-1 (CD11a/CD18). It is constitutively and highly expressed on all leukocytes, playing a critical role in the early stages of adaptive immune responses by facilitating the initial contact between naïve T cells and antigen-presenting cells. Beyond mediating cell-cell adhesion, CD50 itself functions as a potent signaling molecule; its cross-linking triggers intracellular signaling events such as elevated calcium flux in T cells, and it can act as a costimulatory molecule to promote T-cell activation and proliferation. Furthermore, CD50 expression levels are closely associated with T-cell differentiation and maturation status, being expressed at higher levels on memory T cells than on naïve T cells, and it is also involved in the clearance of apoptotic neutrophils.