MSP1D1E3 His Tag Protein, Human (Nanodisc)

The soluble lipid bilayer nanodisc has proven to be a widely applicable method for membrane proteins as soluble in aqueous solutions, which can monodisperse and active membrane protein in a closely native bilayer environment. The key component of the nanodisc is the surrounding amphiphilic spiral protein band (membrane scaffold protein). Nanodisc systems have been used to reconstruction a variety of proteins including GPCRs, P450, bacterial rhodopsin, clotting factors, and tar receptors. Membrane scaffold protein 1E3 with larger inner diameter for twelve transmembrane membrane protein has been used as a scaffold protein for stabilizing lipid nanodiscs (ND). Membrane scaffold protein 1E3 (MSP1D1E3) is modified versions of apolipoprotein A1. It is a biparental synthetic protein that can self-assemble to form nanodiscs. The diameter of MSP1D1E3 is about 12 nm.