Immobilized Mouse alpha-Synuclein Protein, His Tag at 1 μg/mL (100 μL/well) can bind α-Synuclein Recombinant Rabbit mAb (S-441-86) (Cat. No. S0B0344) with EC50 of 3.5-4.4 ng/ml.
Mouse alpha-Synuclein Protein, His Tag
Mouse alpha-Synuclein Protein, His Tag
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor (NACP), Snca, Syn |
| Accession | O55042 |
| Amino Acid Sequence | Protein sequence (O55042, Met1-Ala140, with N-His tag) MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 16.8 kDa Observed MW: 18 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | with N-His tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. It plays a role in restricting the mobility of synaptic vesicles, consequently attenuating synaptic vesicle recycling and neurotransmitter release.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
