Monkey IP-10/CXCL10 Single Plex Kit (Flow Cytometry Bead Assay)

Interferon-gamma-inducible protein 10 (IP-10), officially designated CXCL10, is a small chemokine belonging to the CXC subfamily. It is secreted by a broad range of cells—including monocytes, endothelial cells, keratinocytes, and fibroblasts—upon exposure to type I and type II interferons, particularly IFN-γ. IP-10 exerts its chemoattractant activity via the G protein-coupled receptor CXCR3, which is predominantly expressed on activated Th1 lymphocytes, NK cells, and CD8⁺ T cells. Through this axis, IP-10 orchestrates the recruitment of effector immune cells to inflamed or infected tissues, making it a critical player in antiviral immunity, tumor immunosurveillance, and the pathogenesis of Th1-driven autoimmune conditions such as multiple sclerosis, psoriasis, and type 1 diabetes. Monkey IP-10/CXCL10 denotes the orthologous protein from non-human primates, most commonly cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta). It shares exceptionally high amino acid identity with its human counterpart, preserving both receptor-binding affinity and biological activity across species. This high conservation underpins the extensive use of monkey IP-10 in preclinical pharmacology and toxicology studies, where it serves as a pharmacodynamic biomarker for immune activation and as a target for evaluating CXCR3-selective antagonists, monoclonal antibodies, and small-molecule inhibitors designed to modulate excessive inflammation.