MIP-1α/CCL3 Protein, Human

Catalog Number: UA040164 Brand: UA BIOSCIENCE

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$159 USD

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Product Details

Product Specification

Species	Human
Synonyms	C-C motif chemokine 3, MIP-1-alpha, Macrophage inflammatory protein 1-alpha, LD78-alpha
Accession	P10147
Amino Acid Sequence	Ser24-Ala92
Expression System	E.coli
Molecular Weight	10kDa (Reducing)
Purity	＞95% by SDS-PAGE & RP-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Rheumatol Ther. 2023 Aug;10(4):793-808.Epub 2023 May 25. 2.Adv Exp Med Biol. 2020:1231:13-21. 3.Contrast Media Mol Imaging. 2022 Jul 12:2022:2387192. eCollection 2022.

Background

Chemokines are a class of cytokines that can cause cells to undergochemotactic movement, and their main role in the body is in chemotactic cellmigration. They are widely expressed in various tissues and cells of the body,and their receptors are mainly expressed in white blood cells, mediating thedirectional migration of white blood cells to play a biological role. CCL3, oneof the components of the chemokinep CC ligand family was also termed as MIP(macrophage inflammatory protein). It can be expressed on the surface ofmacrophages, lymphocytes, epithelial cells, and other cells. It mediates thesecretion of cytokines by immune cells and promotes the aggregation andmigration of a variety of cells. C-C motif chemokine receptor 1 (CCR1) and CCR5are the receptors of CCL3.C-C motif chemokine ligand 3 (CCL3) belongs toinflammatory cell chemokine. CCL3 or macrophageinflammatory protein-1α (MIP-1α), an important chemokine implicated in bothimmune surveillance and tolerance, has emerged as a prognostic biomarker inboth solid and hematological malignancies.