Invivo anti-Mouse CD54 (ICAM-1) Recombinant mAb

CD54, commonly known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that plays a pivotal role in immune responses and inflammation by mediating cell-cell adhesion through high-affinity binding to β2 integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) on leukocytes. Expressed constitutively at low levels on endothelial cells and various leukocytes but rapidly upregulated by pro-inflammatory cytokines like TNF-α and IL-1, ICAM-1 facilitates critical physiological processes including leukocyte extravasation across the vascular endothelium, antigen presentation via the immunological synapse between T cells and antigen-presenting cells, and lymphocyte homing. Beyond its essential immune functions, CD54 serves as the primary cellular receptor for human rhinoviruses and certain strains of Plasmodium falciparum-infected erythrocytes, linking it directly to infectious pathogenesis, while its aberrant overexpression is implicated in autoimmune disorders, atherosclerosis, transplant rejection, and tumor metastasis, making it a significant biomarker and therapeutic target for modulating inflammatory and malignant diseases.