IFIT2 Recombinant Rabbit mAb (S-6029)

IFIT2 (interferon-induced protein with tetratricopeptide repeats 2, also known as ISG54 or GARG-39) is an interferon-stimulated gene (ISG) encoded by the IFIT2 gene, belonging to the IFIT protein family, whose core function is to serve as a key effector in intracellular viral recognition and restriction. This protein contains multiple tetratricopeptide repeat (TPR) domains, which confer its unique ability to interact with proteins, enabling it to bind and neutralize key components of viral invasion from various viruses, such as recognizing viral mRNA lacking 2'-O-methylated cap structures or binding to viral RNA polymerase complexes, thereby directly inhibiting viral mRNA translation initiation or replication processes. Beyond its classical antiviral functions, accumulating evidence has revealed the complex roles of IFIT2 in tumor biology: on one hand, it exhibits tumor-suppressive properties in cancers such as gastric cancer and melanoma by promoting the resolution of cancer-associated inflammation or enhancing immune surveillance, with its high expression typically correlating with better patient prognosis; on the other hand, in certain tumor types or specific microenvironments, IFIT2 may also be hijacked by tumor cells to promote metastasis and chemoresistance through regulating epithelial-mesenchymal transition (EMT) or activating specific survival pathways, and this functional duality makes it a hotspot molecule in cancer research. In addition, IFIT2 expression is finely regulated by both interferon and non-interferon signals, and its gene polymorphisms are associated with various autoimmune diseases and viral susceptibility, while significant expression changes have also been observed in non-infectious stress responses such as ischemia-reperfusion injury, indicating broader biological functions of this protein beyond immune defense.