Human NNMT Protein, His Tag

Catalog Number: S0A0194 Brand: Starter

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$420 USD

Size: 10μg 25μg 50μg 100μg

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Product Details

Product Specification

Species	Human
Synonyms	Nicotinamide N-methyltransferase, NNMT
Accession	P40261
Amino Acid Sequence	Protein sequence (P40261, Met1-Leu264, with C-His Tag) MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
Expression System	E.coli
Molecular Weight	Predicted MW: 31.3 kDa Observed MW: 30 kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (vitamin B3) using S-adenosyl methionine (SAM) as the methyl donor, producing S-adenosylhomocysteine (SAH) and 1-methylnicotinamide (MNA). Its overexpression is implicated in various cancers, metabolic disorders, and aging, as it consumes SAM and influences global epigenetic patterns by altering the SAM:SAH ratio. NNMT is now recognized as a key metabolic enzyme with potential as a therapeutic target for cancer and obesity.

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SDS-PAGE

2μg（R: reducing conditions）

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Human NNMT Protein, His Tag