Immobilized Human IL-5 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha / CD125 Protein, Fc Tag with EC50 of 13.4-16.6 ng/ml.
Human IL-5 Protein, His Tag
Human IL-5 Protein, His Tag
Price:
Regular price
$170 USD
Regular price
Sale price
$170 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor (TRF), IL5 |
| Accession | P05113 |
| Amino Acid Sequence | Protein sequence (P05113, Ile20-Ser134, with N-His Tag) IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 15.4 kDa Observed MW: 20 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Interleukin-5 (IL-5) is a crucial cytokine primarily produced by type 2 helper T (Th2) cells and group 2 innate lymphoid cells (ILC2s). Its principal biological function is to regulate the growth, differentiation, recruitment, and survival of eosinophils, a type of white blood cell central to immune responses against parasitic infections, particularly helminths. IL-5 also plays a significant role in allergic diseases, such as asthma and atopic dermatitis, by promoting eosinophilia and IgE production. Furthermore, it supports the maturation and antibody secretion of B cells. Due to its pivotal role in eosinophil-mediated inflammation, IL-5 and its receptor are major therapeutic targets for monoclonal antibody treatments in severe eosinophilic asthma and other hypereosinophilic syndromes.
Picture
Picture
Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
