Immobilized Human IGFBP5 Protein, hFc Tag at 4 μg/mL (100 μL/well) can bind Recombinant Human IGF-I Protein, C-hFc&His with EC50 of 79.6-89.4 ng/ml.
Human IGFBP5 Protein, hFC Tag
Human IGFBP5 Protein, hFC Tag
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$85 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, IBP5 |
| Accession | P24593 |
| Amino Acid Sequence | Protein sequence (P24593, Leu21-Glu272, with C-hFC tag) LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 54.6 kDa Observed MW: 30, 31, 33, 40, 70 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Insulin-like growth factor-binding protein 5 (IGFBP5) is a key member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGFs). Expressed in various tissues, IGFBP5 modulates cell proliferation, differentiation, and apoptosis through IGF-dependent and IGF-independent mechanisms. It interacts with extracellular matrix components and influences signaling pathways like MAPK and PI3K. IGFBP5 is implicated in physiological processes (e.g., bone development, wound healing) and pathologies, including cancer and fibrosis.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
