Human CCL8 Protein, His Tag

CCL8, also known as Monocyte Chemoattractant Protein-2 (MCP-2), is a small cytokine belonging to the CC chemokine family. It is produced by various cells, including monocytes, fibroblasts, and endothelial cells, often in response to inflammatory stimuli. Its primary function is to recruit immune cells to sites of inflammation or infection by binding to several receptors, most notably CCR1, CCR2, CCR5, and CCR8. Through these interactions, CCL8 directs the migration of monocytes, lymphocytes, eosinophils, and dendritic cells. CCL8 plays a significant role in both antimicrobial defense and the pathogenesis of various diseases. It is implicated in chronic inflammatory conditions, allergic responses, and cancer, where it can influence tumor progression and the tumor microenvironment.